The ‘Mice Lie’: Why AI-Discovered Longevity Drugs Rarely Work for You (Yet)

You Are Not a 25g Rodent

AI is revolutionizing drug discovery by screening millions of molecules against gene expression databases. A recent win was identifying a cardiac glycoside that reduces frailty. In mice.

The problem is the Translation Gap. Mice have different metabolisms, different DNA repair mechanisms, and they die of cancer much more often than heart disease. An AI predicting success in a mouse model has a historically low hit rate for humans (less than 10%). While AI speeds up the search, it doesn’t solve the biology. We validate your skepticism: Don’t rush to buy experimental chemicals just because an algorithm flagged them. Wait for the human safety data (Phase 1 trials).

GrimAge vs. DunedinPACE: Why Most ‘Biological Age’ Tests are a Scam

Stop Measuring Noise, Start Measuring Speed

You send in your saliva, and the report says “Biological Age: 35” (you are 40). You celebrate. Two weeks later, it says 42. What happened?

First-generation clocks (Horvath, PhenoAge) are prone to noise. They are like taking a single photo of your odometer. The new standard, backed by AI analysis of longitudinal studies, is DunedinPACE. This is a speedometer. It tells you how fast you are aging right now (e.g., 0.8 years per calendar year). We explain why you should ignore the “vanity age” tests and invest in the “rate of aging” tests to actually see if your lifestyle changes are working.

The ‘Off-Label’ Wall: Why Your Doctor Won’t Prescribe Rapamycin (And How to Fix It)

The Gap Between Research and the Clinic

If you bring a stack of AI research papers to your General Practitioner and ask for Rapamycin (an immunosuppressant used for longevity), they will say no. They follow “Standard of Care,” which treats disease, not aging.

They are worried about liability. If you get an infection, they get sued. To access these AI-validated “Geroprotectors,” you cannot rely on the traditional system. You must utilize the emerging Longevity Telehealth sector. These providers operate under different protocols, explicitly prescribing off-label for “healthspan,” often requiring you to sign waivers acknowledging the experimental nature of the treatment.

The NAD+ Money Pit: Why AI Models Prefer NR over NMN (The Bioavailability Truth)

Don’t Pay for Expensive Urine

AI models analyzing metabolic pathways have flagged NAD+ decline as a key driver of aging. This sparked a craze for supplements like NMN and NR. NMN is hyped and expensive.

However, chemical analysis shows NMN is a large molecule that struggles to enter cells directly; it often breaks down into NR first. Why pay a premium for NMN if your body turns it into NR anyway? We analyze the “Bioavailability” debate and why recent AI simulations and clinical trials suggest that Nicotinamide Riboside (NR) or simply preserving NAD+ via lifestyle might be the more efficient (and cheaper) route.

AgelessRx vs. Healthspan vs. GetHealth: Best Telehealth for Rapamycin Access

Comparing the “Gatekeepers” of Longevity

You’ve decided to try Rapamycin. You can’t just buy it on Amazon. You need a prescription. Three main startups dominate this space.

AgelessRx: The Amazon of longevity. Cheap, standardized, slow shipping. Good for beginners.
Healthspan: More coaching-focused, integrates bloodwork. Better for data nerds.
GetHealth: Aggregator style.
We compare them on Cost Per Mg (the only metric that really matters) and the rigor of their blood monitoring. You want a provider that mandates bloodwork to watch your lipids and glucose, as Rapamycin can spike both.

Mitopure vs. Generic Urolithin A: Is the AI-Backed Patent Worth 5x the Price?

The Proprietary Molecule Premium

AI research pinpointed Urolithin A as a powerful compound for “Mitophagy” (cleaning out old mitochondria). A Swiss company, Amazentis, patented a stable form called Mitopure. It costs $100+ a month.

Generic Urolithin A creates have popped up for $30. Are they the same? Likely not. The extraction and stability of this molecule are notoriously difficult. Clinical trials that show benefits almost exclusively use the proprietary Mitopure. In this case, the “Brand Name” tax might be the difference between a working supplement and expensive dust. We review the absorption studies.

InsideTracker vs. Function Health: Which AI Dashboard Actually Predicts Disease?

From “Here is your number” to “Here is what to do”

You have 100 vials of blood drawn. You get a PDF. It’s overwhelming. You need an AI layer to interpret it.
InsideTracker focuses on “Optimized Zones” for athletes. It tells you to eat more iron. It’s good for performance.
Function Health (co-founded by Mark Hyman) is the new heavyweight. It tests 100+ biomarkers (including ApoB, hormones, heavy metals) for $499/year and uses a more aggressive AI to flag early disease risk. For the longevity enthusiast, Function offers the deepest data set for the price, effectively replacing your annual physical.

The ‘Clock’ Reversal: How to Actually Lower Your DunedinPACE Score

Moving the Needle on Your Epigenetics

So you scored a 1.05 on DunedinPACE (aging fast). How do you fix it? AI analysis of large cohorts (like the CALERIE study) points to very specific interventions.

Caloric Restriction (CR): Eating 10-15% less is the most proven method.
Zone 2 Cardio: 150+ minutes a week.
Methylation Support: Specific B-vitamins if you have the MTHFR gene.
We validate that “stress reduction” is vague, but “reducing caloric intake” creates a measurable signal on the clock within 6 months.

Peptide Stacking: The AI-Optimized Protocol for Joint Repair (BPC-157 & TB-500)

The “Wolverine” Stack

Aging hurts. Joints wear out. AI simulations of protein folding have identified specific peptides that signal tissue repair. The most famous stack is BPC-157 (Body Protection Compound) and TB-500 (Thymosin Beta-4).

Doctors rarely prescribe these. Users buy them “for research purposes only” and inject them subcutaneously. We discuss the protocols found in the “biohacking underground”: cycling them for 6 weeks to heal injuries. We also address the safety signal—specifically, the concern that promoting “growth” (angiogenesis) could theoretically help cancer grow too. High risk, high reward.

Gene Therapy Tourism: The Risks of ‘Follistatin’ Injections in Prospera

The Wild West of Life Extension

AI has identified Follistatin as a gene that inhibits myostatin (the “muscle growth brake”). More muscle = longer survival. But gene therapy is illegal for this use in the US.

Enter Minicircle, a startup in the special economic zone of Prospera, Honduras. They offer plasmid gene therapy to biohackers for $20,000+. This is the bleeding edge. We discuss the mechanism (it’s reversible, unlike CRISPR) but validate the extreme risk: You are flying to a deregulated zone to inject experimental genetic material. This is for the “dying” or the “reckless,” not the average optimizer.

DIY AI: Using ChatGPT to Analyze Your 23andMe Raw Data for ApoE4 Risks

Be Your Own Genetic Counselor

You don’t need to pay a service $200 to read your DNA. You can download the “Raw Data” (txt file) from 23andMe or Ancestry.

We provide the ChatGPT Prompts to interpret this data. You can paste snippets of your genome (specifically looking for rs429358 and rs7412) to determine your ApoE status (Alzheimer’s risk). You can ask the AI to “Check for MTHFR mutations and suggest dietary changes.” This turns a static file into a dynamic health conversation, completely free.

The Bryan Johnson ‘Blueprint’ Review: What is Science and What is Vanity?

Separating the Signal from the Billionaire Noise

Bryan Johnson is the face of AI longevity. He takes 100 pills and eats sludge. It’s easy to mock him, but his data is real.
However, not everything he does is necessary for you.

Science: Caloric Restriction, Sleep hygiene, Rapamycin, HRT.
Vanity: Measuring nocturnal erections, laser face treatments, taking 50 obscure supplements with marginal evidence.
We help you extract the “Pareto Principle” of Blueprint—do the 20% of his routine that gives 80% of the benefit, and ignore the performative suffering.

The Only 3 Longevity Interventions Worth Paying For in 2025

The Trinity of Lifespan

If you strip away the hype, AI models and clinical data converge on three massive levers for longevity:

Metabolic Control: Keeping glucose low and stable (Metformin, GLP-1s, or low carb).
mTOR Inhibition: Giving cells a “clean up” signal (Fasting or Rapamycin).
Muscle Mass: The organ of longevity. Lifting heavy things.
If you aren’t doing these three, the supplements don’t matter. Spend your money on a gym trainer and a metabolic doctor before you buy a single bottle of Resveratrol.

My Final Verdict: The ‘Minimum Effective Dose’ Longevity Protocol

How to Live Longer Without Being Miserable

You want the benefits of AI-driven research without living in a lab. Here is the protocol:

Test: Get a Function Health panel yearly (ApoB is the priority).
Drug: Ask a telehealth provider about low-dose Rapamycin (if over 40).
Supplement: Creatine (brain/muscle) and Magnesium.
Lifestyle: Sleep 8 hours, Zone 2 cardio, eat whole foods.
This costs <$100/month and captures the vast majority of the “healthspan” gains currently known to science. Ignore the rest until the AI finds something better.